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Recombinant Protein Manufacturing

Separation and Purification Sciences - Lab Capsules
Separation and Purification Sciences

Biopharmaceutical Manufacturing

  • In the biopharmaceutical industry, saving time and bringing efficiencies from the clinic to the market is key to growth. 3M is here to help you achieve that. 3M™ Zeta Plus™ Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier, and 3M™ LifeASSURE™ Filters are single-use products that:

    • enable robust purification platformability across diverse biopharmaceutical modalities
    • is designed for all process stages from lab scale-up to manufacturing

Monoclonal Antibodies Manufacturing

  • Monoclonal antibody (mAb) therapeutics manufacturing requires robust, scalable solutions throughout the process train from clarification to purification. 3M Zeta Plus Depth Filter and 3M Emphaze AEX Hybrid Purifier are uniquely engineered and designed specifically for the biopharmaceutical industry to optimise cell harvest and clarification needs.

    3M Emphaze AEX Hybrid Purifier is the newest single-use technology for polishing stage clarification of mammalian cell culture fluid and is designed to reduce both soluble and insoluble impurities. 3M Emphaze AEX Hybrid Purifier combines two types of media, Q-functional nonwoven and a membrane that works together to provide high clarification efficiency in a single clarification stage. The 3M Zeta Plus Depth Filter and 3M Emphaze AEX Hybrid Purifier enable centrifuge replacement with a scalable single-use system.

Bioprocessing reimagined

You can achieve higher yield through chromatographic clarification of cell culture fluid including the reduction of HCP, DNA, and endotoxins. These solutions enable elimination and/or reduction in the size of unit operations, leading to better overall process economics. This process train illustrates how a combination of 3M products works together to create processing solutions that simplify the purification process and eliminates process steps.

3M Solutions

  • Biopharma process train showing 3M products
Eliminate the centrifuge

The combination of 3M™ Zeta Plus™ Series Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ LifeASSURE™ Membrane Filters may be a compelling alternative to a centrifuge-based Harvest-Clarification process.

Want to learn more? Check out this article.
Comprehensive options

Single-use, encapsulated devices for the removal of cell mass with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.

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Simplify the process

Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.

Download data sheet (PDF, 827.54 KB)

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Quality and Reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA filter capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

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Cost-efficient and compact

3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses, and other negatively charged contaminants in flow-through polishing chromatography.

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Biomanufacturing Purification Platform Product Categories

To help boost your biopharmaceutical manufacturing efficiency, 3M offers a robust portfolio of biopharmaceutical manufacturing products – from membranes and hybrid chromatographic purifiers to depth filtration systems and process hardware. Our filtration and purification products are designed for robust performance, efficiency, and easy scale-up from lab scale to production scale.

  • The goal of harvest and clarification is to prepare your cell culture process fluid for downstream purification by different chromatography unit operations or steps. 3M Zeta Plus Depth Filter and 3M Emphaze AEX Hybrid Purifier help biopharmaceutical drug manufacturers design and deploy robust clarification processes. 3M solutions are designed for recombinant mAbs expressed in mammalian cell cultures and for plasma-derived proteins.

  • Our membrane filters are engineered for high-capacity and fast-flow rates. Our portfolio includes solutions for sterile filtration, bioburden control, and endotoxin reduction. Validated membranes make these filters a reliable choice for process and contaminant control strategy.

  • We combine advanced anion exchanges (AEX) chromatography media, fine fiber nonwovens and fine particle reduction membranes to create novel purification solution. The result is a synthetic, single-use clarifying product that provides high purity.

  • With five standard types of activated carbon filters for a broad range of uses, 3M offers you a high degree of application flexibility. Our filter portfolio is designed for purification of a range of chemical and biological pharmaceutical fluids.

Featured Applications

From cell culture fluid clarification and soluble impurity reduction to mycoplasma retention and final sterilising filtration, our technologies deliver economical, robust solutions for a wide variety of applications within biopharmaceutical production.

  • Clarification tools are designed for particle size control in the clarified cell culture fluid. 3M offers efficient depth filters that enable high throughput. This can eliminate the need for centrifugation and enables the implementation of a fully single-use clarification process train, completely scalable from lab to pilot to manufacturing scale.

  • Reduce insoluble impurities to help prevent plugging or fouling of capture and polishing chromatography columns.

  • Reduce microorganisms and control fine particles downstream.

  • Reduce DNA to target specification to help meet U.S. FDA requirements for protein therapeutic formulations.

Need Help Finding the Right Bioprocessing Product?

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate product in-use.