Our apologies.
An error has occurred while submitting. Please try again later..
Thank you.
Your form was submitted successfully.
Our apologies...
An error has occurred while submitting. Please try again later...
Thank you!
Your form was submitted successfully
Next-generation harvest technology
Single-step chromatographic purification at the harvest and clarification stages for recombinant protein therapeutic manufacturing
Need help streamlining your process?
Next-generation bioprocessing
The newest 3M solution, 3M™ Harvest RC, utilises fibrous anion exchange (AEX) chromatography to efficiently separate cells, cell debris and DNA from the harvest fluid containing the target product. Precision quaternary ammonium (Q) functionalized polypropylene fiber, combined with a 0.2 µm PES membrane, provides predictable clarification that is scalable from discovery to commercial manufacturing.
3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses and other negatively charged contaminants in flow-through polishing chromatography.
View all products3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses and other negatively charged contaminants in flow-through polishing chromatography.
View all products- • Removes soluble and insoluble contaminants
- • Turbidity reduction from >2000 to <15 NTU
- • High mAb recovery, >95%
View all products
- • Removes soluble and insoluble contaminants
- • Turbidity reduction from >2000 to <15 NTU
- • High mAb recovery, >95%
View all products
Virtual trial of 3M Harvest RC
Innovative design and performance
3M Harvest RC enables a single-stage clarification process of low- to high-density cell culture (> 40 million cells per mL) with high recovery, and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration.
-
Key Trends Reshaping the Future of Bio-Pharmaceutical Harvest & ClarificationCell harvesting and clarifications are both crucial steps that can have a significant impact on the design of downstream processes. As processes change upstream in the pharmaceutical manufacturing workflow, causing variability of cell culture fluid, downstream purification unit operations will be impacted. -
3M Harvest RC: Powering Single Stage ClarificationRead an analysis by Frost & Sullivan on how 3M Harvest RC transforms the clarification process by replacing centrifuge and depth filtration steps, improves process efficiencies and scales effectively with a wide range of product formats.
-
A Frost & Sullivan Perspective on Next Generation Harvest TechniquesAcademic and industry leaders in biopharmaceutical manufacturing participated in a thought leadership forum, the Virtual Think Tank series, to discuss challenges, strategies, techniques, and barriers to new technology implementation in monoclonal antibody harvesting.
-
3M Harvest RC: Re-imagining ClarificationRead a Frost & Sullivan analysis of how 3M Harvest RC re-imagines the clarification process to address challenges posed by global biologics trends.
Other resources
Find more detail about 3M Harvest RC, a new single-stage, single-use chromatographic purification and clarification solution. It is designed as an efficient option to increase monoclonal antibody (mAb) yields while streamlining the upstream process by replacing the centrifuge and/or depth filtration process steps.
